Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol)

被引：15
|
作者：
Liu, Di [1 ]
Bielawski, Christopher W. [2 ,3 ,4 ]
机构：
[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA
[2] Inst Basic Sci, CMCM, Ulsan 44919, South Korea
[3] Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea
[4] Ulsan Natl Inst Sci & Technol, Dept Energy Engn, Ulsan 44919, South Korea
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2016年 / 37卷 / 19期
基金：
新加坡国家研究基金会; 美国国家科学基金会;
关键词：
biodegradable polymers; drug delivery systems; poly(ethylene glycol); post-polymerization modification; ruthenium; DRUG-DELIVERY; RUTHENIUM TETROXIDE; PEGYLATION; OXIDATION; PEG; THERAPEUTICS;
D O I：
10.1002/marc.201600336
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium- catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions.
引用
收藏
页码：1587 / 1592
页数：6
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