Experience of adjunctive cannabis use for chronic non-cancer pain: Findings from the Pain and Opioids IN Treatment (POINT) study

被引:94
|
作者
Degenhardt, Louisa [1 ,2 ]
Lintzeris, Nicholas [3 ,4 ]
Campbell, Gabrielle [1 ]
Bruno, Raimondo [1 ,5 ]
Cohen, Milton [6 ]
Farrell, Michael [1 ]
Hall, Wayne D. [7 ,8 ]
机构
[1] Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
[2] Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia
[3] Univ Sydney, Discipline Addict Med, Sydney, NSW 2006, Australia
[4] Langton Ctr, South East Sydney Local Hlth Dist SESLHD Drug & A, Surry Hills, Australia
[5] Univ Tasmania, Sch Med, Hobart, Tas 7001, Australia
[6] Univ New S Wales, UNSW Med, St Vincents Clin Sch, Sydney, NSW 2052, Australia
[7] Univ Queensland, Ctr Youth Substance Abuse Res, Brisbane, Qld 4072, Australia
[8] Kings Coll London, Natl Addict Ctr, London WC2R 2LS, England
基金
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词
Cannabis; Chronic pain; Pharmaceutical opioids; Medical cannabis use; Australia; CLINICAL-TRIALS;
D O I
10.1016/j.drugalcdep.2014.11.031
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: There is increasing debate about cannabis use for medical purposes, including for symptomatic treatment of chronic pain. We investigated patterns and correlates of cannabis use in a large community sample of people who had been prescribed opioids for chronic non-cancer pain. Methods: The POINT study included 1514 people in Australia who had been prescribed pharmaceutical opioids for chronic non-cancer pain. Data on cannabis use, ICD-10 cannabis use disorder and cannabis use for pain were collected. We explored associations between demographic, pain and other patient characteristics and cannabis use for pain. Results: One in six (16%) had used cannabis for pain relief, 6% in the previous month. A quarter reported that they would use it for pain relief if they had access. Those using cannabis for pain on average were younger, reported greater pain seventy, greater interference from and poorer coping with pain, and more days out of role in the past year. They had been prescribed opioids for longer, were on higher opioid doses, and were more likely to be non-adherent with their opioid use. Those using cannabis for pain had higher pain interference after controlling for reported pain severity. Almost half (43%) of the sample had ever used cannabis for recreational purposes, and 12% of the entire cohort met criteria for an ICD-10 cannabis use disorder. Conclusions: Cannabis use for pain relief purposes appears common among people living with chronic non-cancer pain, and users report greater pain relief in combination with opioids than when opioids are used alone. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:144 / 150
页数:7
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