Electronic tuning of chiral diene ligands in iridium-catalyzed asymmetric 1,6-addition of arylboroxines to δ-aryl-α,β,γ,δ-unsaturated ketones

被引：51

作者：

Nishimura, Takahiro ^{[1
]}

Noishiki, Akira ^{[1
]}

Hayashi, Tamio ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 07期

关键词：

ENANTIOSELECTIVE 1,6-CONJUGATE ADDITION; GRIGNARD-REAGENTS; CONJUGATE ADDITION; BORONIC ACIDS; ARYL; TETRAFLUOROBENZOBARRELENES; 1,4-ADDITION;

D O I：

10.1039/c2cc16973h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric addition of arylboroxines to delta-aryl-alpha,beta,gamma,delta-unsaturated ketones proceeded in the presence of an iridium catalyst coordinated with a chiral diene ligand to give high yields of delta-diaryl ketones with very high enantioselectivity.

引用

页码：973 / 975

页数：3

共 40 条

[1] Iridium/Chiral Diene-Catalyzed Asymmetric 1,6-Addition of Arylboroxines to α,β,γ,δ-Unsaturated Carbonyl Compounds
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[2] Chiral Tetrafluorobenzobarrelenes as Effective Ligands for Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboroxines to β,β-Disubstituted α,β-Unsaturated Ketones
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[4] Highly selective 1,6-addition of aryl boronic acids to α,β,γ,δ-unsaturated carbonyl compounds catalyzed by an iridium complex
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[8] Chiral Phosphite-Olefin Ligands: Application in Rh-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to β-Aryl-α,β-unsaturated Sulfonates
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[9] Electronic and steric tuning of chiral diene ligands for rhodium-catalyzed asymmetric arylation of imines
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[10] Chiral pyridyl phosphinites with large aryl substituents as efficient ligands for the asymmetric iridium-catalyzed hydrogenation of difficult substrates
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