Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment

被引：23

作者：

Goukasian, Naira ^{[1
]}

Porat, Shai ^{[2
]}

Blanken, Anna ^{[2
]}

Avila, David ^{[3
]}

Zlatev, Dimitar ^{[4
]}

Hurtz, Sona ^{[5
]}

Hwang, Kristy S. ^{[6
]}

Pierce, Jonathan ^{[7
]}

Joshi, Shantanu H. ^{[7
]}

Woo, Ellen ^{[7
]}

Apostolova, Liana G. ^{[8
,9
,10
]}

机构：

[1] Univ Vermont, Larner Coll Med, Burlington, VT USA

[2] Univ Southern Calif, Dept Psychol, Los Angeles, CA 90089 USA

[3] Univ Calif Irvine, Irvine Sch Med, Irvine, CA USA

[4] Massachusetts Gen Hosp, Boston, MA 02114 USA

[5] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA

[6] Emory Univ, Sch Med, Atlanta, GA USA

[7] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[8] Indiana Univ Sch Med, Dept Neurol, 355 W 16th St,Suite 4022, Indianapolis, IN 46202 USA

[9] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA

[10] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2019年 / 9卷 / 02期

关键词：

Alzheimer's disease; Mild cognitive impairment; Imaging; MRI; Hippocampal atrophy; Ventricular enlargement; ADNI HARMONIZED PROTOCOL; ALZHEIMERS-DISEASE; MAGNETIC-RESONANCE; MAPPING HIPPOCAMPAL; SEGMENTATION; VOLUME; BRAIN; MRI; DEMENTIA; VALIDATION;

D O I：

10.1159/000490044

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method.Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors.

引用

页码：281 / 293

页数：13

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