Quantitative cognitive-test characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation

被引：9

作者：

Fedotov, I. V. ^{[1
,2
,3
]}

Ivashkina, O. I. ^{[3
,4
]}

Pochechuev, M. S. ^{[3
,4
]}

Roshchina, M. A. ^{[3
,4
]}

Toropova, K. A. ^{[3
,4
]}

Fedotov, A. B. ^{[1
,3
]}

Anokhin, K. V. ^{[4
]}

Zheltikov, A. M. ^{[1
,2
,3
,4
]}

机构：

[1] Moscow MV Lomonosov State Univ, Phys Dept, Int Laser Ctr, Moscow 119992, Russia

[2] Texas A&M Univ, Dept Phys & Astron, College Stn, TX 77843 USA

[3] Russian Quantum Ctr, Ul Novaya 100, Skolkovo 143025, Moscow Region, Russia

[4] Natl Res Ctr, Kurchatov Inst, Pl Akad Kurchatova 1, Moscow 123182, Russia

来源：

JOURNAL OF BIOPHOTONICS | 2017年 / 10卷 / 11期

关键词：

Neurophotonics; fiber-optic neurointerfaces; OPTICAL CONTROL; CHANNELRHODOPSIN-2; STIMULATION; NEURONS; CORTEX;

D O I：

10.1002/jbio.201600225

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cognitive tests on representative groups of freely behaving transgenic mice are shown to enable a quantitative characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation. A systematic analysis of such tests provides a robust quantitative measure for the cognitive effects induced by fiber-optic neurostimulation, validating the performance of fiber-optic neurointerfaces for long-term optogenetic brain stimulations and showing no statistically significant artifacts in the behavior of transgenic mice due to interface implantation.

引用

页码：1485 / 1491

页数：7