Proline-mediated enantioselective construction of tetrahydropyridines via a cascade Mannich-Type/Intramolecular Cyclization reaction

被引：59
|
作者：
Han, Rong-Gang [1 ]
Wang, Yao [1 ]
Li, Yu-Ye [1 ]
Xu, Peng-Fei [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 10期
关键词：
cascade reactions; imines; Mannich-type; reaction; organocatalysis; tetrahydropyridines;
D O I：
10.1002/adsc.200800253
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A highly diastereo- and enantioselective synthesis of 2,3-disubstituted tetrahydropyridines was accomplished via a proline-mediated cascade Mannich-type/intramolecular cyclization reaction from preformed N-PMP (p-methoxyphenyl) aldimines and inexpensive aqueous tetrahydro-2Hpyran-2,6-diol.
引用
收藏
页码：1474 / 1478
页数：5
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