Deficiency of cholesterol 7α hydroxylase (Cyp7a1) in bile acid synthesis exacerbates alcohol-induced liver injury in mice

被引：0
|
作者：
Donepudi, Ajay C. [1 ]
Ferrell, Jessica M. [1 ]
Boehme, Shannon M. [1 ]
Chiang, John [1 ]
机构：
[1] Northeast Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH USA
来源：
HEPATOLOGY | 2017年 / 66卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1978
引用
收藏
页码：1048A / 1048A
页数：1
相关论文
共 50 条
  • [1] Deficiency of Cholesterol 7α-Hydroxylase in Bile Acid Synthesis Exacerbates Alcohol-Induced Liver Injury in Mice
    Donepudi, Ajay C.
    Ferrell, Jessica M.
    Boehme, Shannon
    Choi, Hueng-Sik
    Chiang, John Y. L.
    HEPATOLOGY COMMUNICATIONS, 2018, 2 (01) : 99 - 112
  • [2] Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
    Pullingr, CR
    Eng, C
    Salen, G
    Shefer, S
    Batta, AK
    Erickson, SK
    Verhagen, A
    Rivera, CR
    Mulvihill, SJ
    Malloy, MJ
    Kane, JP
    JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (01): : 109 - 117
  • [3] Bile acid induced signal transductive pathways involved in regulation of cholesterol 7a-hydroxylase (CYP7A1) transcription.
    Gupta, S
    Stravitz, RT
    Dent, P
    Vlahcevic, ZR
    Hylemon, PB
    GASTROENTEROLOGY, 2000, 118 (04) : A2 - A2
  • [4] Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis
    Pandak, WM
    Schwarz, C
    Hylemon, PB
    Mallonee, D
    Valerie, K
    Heuman, DM
    Fisher, RA
    Redford, K
    Vlahcevic, ZR
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 281 (04): : G878 - G889
  • [5] PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE DEFICIENCY EXACERBATES ALCOHOL-INDUCED LIVER INJURY IN MICE
    Chava, Srinivas
    Arumugam, Madan Kumar
    Paal, Matthew C.
    Murphy, Ireland M.
    Rasineni, Karuna
    Donohue, Terrence M., Jr.
    Osna, Natalia A.
    Kharbanda, Kusum K.
    HEPATOLOGY, 2021, 74 : 243A - 243A
  • [6] Role of Cholesterol 7α-Hydroxylase (CYP7A1) in Nutrigenetics and Pharmacogenetics of Cholesterol Lowering
    Jaroslav A. Hubacek
    Dagmar Bobkova
    Molecular Diagnosis & Therapy, 2006, 10 : 93 - 100
  • [7] Role of cholesterol 7α-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering
    Hubacek, Jaroslav A.
    Bobkova, Dagmar
    MOLECULAR DIAGNOSIS & THERAPY, 2006, 10 (02) : 93 - 100
  • [8] Species-specific mechanisms for cholesterol 7α-hydroxylase (CYP7A1) regulation by drugs and bile acids
    Handschin, C
    Gnerre, C
    Fraser, DJ
    Martinez-Jimenez, C
    Jover, R
    Meyer, UA
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 434 (01) : 75 - 85
  • [9] Regulation of the human cholesterol 7α-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice
    Drover, VAB
    Agellon, LB
    ENDOCRINOLOGY, 2004, 145 (02) : 574 - 581
  • [10] GPR30, a Novel Estrogen Receptor, Enhances Cholesterol Cholelithogenesis by Inhibiting Cholesterol 7α-Hydroxylase (CYP7A1) and the Classic Pathway of Bile Acid Synthesis
    de Bari, Ornella
    Wang, Helen H.
    Paik, Changnyol
    Garruti, Gabriella
    Liu, Min
    Portincasa, Piero
    Wang, David Q.
    GASTROENTEROLOGY, 2013, 144 (05) : S254 - S254
12345