Experimental developments in movement disorders: update on proposed free radical mechanisms

被引：37
|
作者：
Przedborski, S [1 ]
Jackson-Lewis, V [1 ]
机构：
[1] Columbia Univ, Dept Neurol, Div Movement Disorders, New York, NY 10032 USA
来源：
CURRENT OPINION IN NEUROLOGY | 1998年 / 11卷 / 04期
关键词：
D O I：
10.1097/00019052-199808000-00009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Free radicals have been implicated in the pathogenesis of movement disorders such as Parkinson's disease and Huntington's disease. Some basic aspects about free radicals as they relate to oxidative stress in neurodegeneration are summarized. Old and new experimental findings pertinent to oxidative damage in movement disorders are reviewed. Finally, the degree to which toxin-induced and genetically engineered experimental models have been useful in delineating parts of the mechanisms involved in the cascade of events that lead to neuronal death is emphasized. (C) 1998 Lippincott-Raven Publishers.
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页码：335 / 339
页数：5
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