Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp.

被引：59
|
作者：
Aoki, S
Yoshioka, Y
Miyamoto, Y
Higuchi, K
Setiawan, A
Murakami, N
Chen, ZS
Sumizawa, T
Akiyama, S
Kobayashi, M
机构：
[1] Osaka Univ, Fac Pharmaceut Sci, Suita, Osaka 565, Japan
[2] Kagoshima Univ, Fac Med, Inst Canc Res, Kagoshima 890, Japan
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期
关键词：
steroids and sterols; sponges; antitumour compounds; stereochemistry;
D O I：
10.1016/S0040-4039(98)01336-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Agosterol A (1) has been isolated from a marine sponge of Spongia sp. and the absolute stereostructure elucidated. Agosterol A (1) is a novel polyhydroxylated sterol acetate, which completely reverses multidrug resistance in human carcinoma cells caused by overexpression of two kinds of membrane glycoprotein. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6303 / 6306
页数：4
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