Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment

被引：11
|
作者：
Jay-Gerin, J-P [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Sci Sante, Dept Med Nucl & Radiobiol, 3001,12e Ave Nord, Sherbrooke, PQ J1H 5N4, Canada
来源：
CANCER RADIOTHERAPIE | 2020年 / 24卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Liquid water; Radiolysis; Chemical yield; Hydronium ion (H3O+); pH; Acid spike; Monte Carlo track chemistry simulation; FLASH radiotherapy; HYDROGEN-PEROXIDE; HIGH-INTENSITY; RADIOLYSIS; WATER; PH; CELLS;
D O I：
10.1016/j.canrad.2019.11.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Monte Carlo simulations of gamma/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient "acid-spike" response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：332 / 334
页数：3
相关论文
共 50 条
  • [1] Ultra-high dose-rate proton FLASH improves tumor control
    Shukla, Samriddhi
    Saha, Taniya
    Rama, Nihar
    Acharya, Anusha
    Le, Tien
    Bian, Fenghua
    Donovan, Johnny
    Tan, Lin Abigail
    Vatner, Ralph
    Kalinichenko, Vladimir
    Mascia, Anthony
    Perentesis, John P.
    Kalin, Tanya, V
    RADIOTHERAPY AND ONCOLOGY, 2023, 186
  • [2] Development of Ultra-High Dose-Rate (FLASH) Particle Therapy
    Kim, Michele M.
    Darafsheh, Arash
    Schuemann, Jan
    Dokic, Ivana
    Lundh, Olle
    Zhao, Tianyu
    Ramos-Mendez, Jose
    Dong, Lei
    Petersson, Kristoffer
    IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, 2022, 6 (03) : 252 - 262
  • [3] Formation of early, transient, strongly acidic spikes in the proton radiolysis of water at ultra-high (flash) dose rates (vol 94, pg S77, 2022)
    Alanazi, A.
    Sultana, A.
    Meesungnoen, J.
    Jay-Gerin, J. -p.
    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2022, 103 : 200 - 200
  • [4] Faster and safer? FLASH ultra-high dose rate in radiotherapy
    Durante, Marco
    Brauer-Krisch, Elke
    Hill, Mark
    BRITISH JOURNAL OF RADIOLOGY, 2018, 91 (1082):
  • [5] The Importance and Clinical Implications of FLASH Ultra-High Dose-Rate Studies for Proton and Heavy Ion Radiotherapy
    Colangelo, Nicholas W.
    Azzam, Edouard I.
    RADIATION RESEARCH, 2020, 193 (01) : 1 - 4
  • [6] ULTRA-HIGH DOSE-RATE, PULSE IRRADIATION TO REDUCE THE COMPLICATIONS OF RADIOTHERAPY
    Favaudon, V.
    Pouzoulet, F.
    Fontaine, J. J.
    Caplier, L.
    Sayarath, M.
    Vozenin-Brotons, M. C.
    RADIOTHERAPY AND ONCOLOGY, 2011, 98 : S11 - S11
  • [7] Ultra-high dose rate (FLASH) radiotherapy: Revolutionizing tumor targeting and microenvironmental dynamics in cancer treatment
    Wang Zhiming
    Zhou Guangming
    Zhang Yongsheng
    Cao Zhifei
    中华医学杂志英文版, 2024, 137 (24)
  • [8] Investigating the mechanisms behind salivary gland tissue sparing in response to ultra-high dose-rate FLASH proton radiotherapy
    Morcos, George S.
    Chowdhury, Priyanka
    Kim, Michele M.
    Shoniyozov, Khayrullo
    Metz, James
    Dong, Lei
    CANCER RESEARCH, 2024, 84 (06)
  • [9] Ultra-high dose rate (FLASH) radiotherapy: Revolutionizing tumor targeting and microenvironmental dynamics in cancer treatment
    Wang, Zhiming
    Zhou, Guangming
    Zhang, Yongsheng
    Cao, Zhifei
    CHINESE MEDICAL JOURNAL, 2024, 137 (24) : 3148 - 3150
  • [10] Generation of ultrafast, transient, highly acidic pH spikes in the radiolysis of water at very high dose rates: relevance for FLASH radiotherapy
    Sultana, Abida
    Alanazi, Ahmed
    Meesungnoen, Jintana
    Jay-Gerin, Jean-Paul
    CANADIAN JOURNAL OF CHEMISTRY, 2022, 100 (04) : 272 - 279
12345