Voxel-based morphometry study on brain structure in children with high-functioning autism

被引：65
|
作者：
Ke, Xiaoyan [1 ,2 ]
Hong, Shanshan [2 ]
Tang, Tianyu [2 ]
Zou, Bing [1 ]
Li, Huiguo [1 ]
Hang, Yueyue [1 ]
Zhou, Zhenyu [2 ]
Ruan, Zongcai [2 ]
Lu, Zuhong [2 ]
Tao, Guotai [1 ]
Liu, Yijun [3 ]
机构：
[1] Nanjing Med Univ, Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing 210029, Peoples R China
[2] Southeast Univ, Key Lab Child Dev & Learning Sci, Minist Educ, Nanjing, Peoples R China
[3] Univ Florida, McKnight Brain Inst, Dept Psychiat & Neurosci, Gainesville, FL 32611 USA
来源：
NEUROREPORT | 2008年 / 19卷 / 09期
关键词：
brain structure; children; high-functioning autism; magnetic resonance imaging; morphometry;
D O I：
10.1097/WNR.0b013e328300edf3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Earlier studies have suggested abnormal brain volumes in autism, but inconsistencies exist. Using voxel-based morphometry, we compared global and regional brain volumes in 17 high-functioning autistic children with 15 matched controls. We identified significant reduction in left white matter volume and white/gray matter ratio in autism. Regional brain volume reductions were detected for right anterior cingulate, left superior parietal lobule white matter volumes, and right parahippocampal gyrus gray matter volume, whereas enlargements in bilateral supramarginal gyrus, right postcentral gyrus, right medial frontal gyrus, and right posterior lobe of cerebellum gray matter in autism. Our findings showed global and regional brain volumes abnormality in high-functioning autism.
引用
收藏
页码：921 / 925
页数：5
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