MUTYH-associated polyposis (MAP)

被引：107
|
作者：
Nielsen, Maartje [1 ]
Morreau, Hans [2 ]
Vasen, Hans F. A. [3 ,4 ]
Hes, Frederik J. [1 ]
机构：
[1] Leiden Univ Med Ctr, Dept Clin Genet, NL-2333 ZA Leiden, Netherlands
[2] Leiden Univ Med Ctr, Dept Pathol, NL-2333 ZA Leiden, Netherlands
[3] Leiden Univ Med Ctr, Dutch Hereditary Canc Registry, NL-2333 ZA Leiden, Netherlands
[4] Leiden Univ Med Ctr, Dept Gastroenterol, NL-2333 ZA Leiden, Netherlands
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2011年 / 79卷 / 01期
关键词：
MUTYH-associated polyposis; MUTYH gene; MAP; Colorectal cancer; Polyposis; MYH-ASSOCIATED POLYPOSIS; BASE-EXCISION-REPAIR; SPORADIC COLORECTAL-CANCER; FAMILIAL ADENOMATOUS POLYPOSIS; C-TERMINAL DOMAIN; BIALLELIC GERMLINE MUTATIONS; ADENINE-DNA GLYCOSYLASE; ESCHERICHIA-COLI MUTY; CLASS-I EXPRESSION; HUMAN HOMOLOG;
D O I：
10.1016/j.critrevonc.2010.05.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene and protein, the clinical impact of mono- and biallelic MUTYH mutations and histological aspects of the MUTYH tumors. Furthermore, the relationship between MUTYH and the mismatch repair genes in colorectal cancer (CRC) families is examined. Finally, the role of other base excision repair genes in polyposis and CRC patients is discussed. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 16
页数：16
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