Dynamic Kinetic Resolution of Azlactones Catalyzed by Chiral Bronsted Acids

被引：64
|
作者：
Lu, Guojian [1 ]
Birman, Vladimir B. [1 ]
机构：
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 03期
基金：
美国国家科学基金会;
关键词：
ASYMMETRIC CATALYSIS; BENZOTETRAMISOLE; PROTONATION;
D O I：
10.1021/ol102736t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral Bronsted acids have been shown for the first time to catalyze the dynamic kinetic resolution of azlactones. 3,3'-Bis-(9-anthryl)-BINOL phosphoric acid 3c is particularly effective in the case of 4-aryl-substituted substrates, producing 85-92% ee's.
引用
收藏
页码：356 / 358
页数：3
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