Development of fluorescence oligonucleotide probes based on cytosine- and guanine-rich sequences

被引:6
|
作者
Dembska, Anna [1 ]
Switalska, Angelika [1 ]
Fedoruk-Wyszomirska, Agnieszka [2 ]
Juskowiak, Bernard [1 ]
机构
[1] Adam Mickiewicz Univ, Fac Chem, Uniwersytetu Poznanskiego 8, PL-61614 Poznan, Poland
[2] Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-60704 Poznan, Poland
关键词
AGGREGATION-INDUCED EMISSION; I-MOTIF; G-QUADRUPLEX; MOLECULAR BEACONS; SILVER CLUSTERS; NUCLEIC-ACIDS; TELOMERIC DNA; LABEL-FREE; COMPLEXES; WATER;
D O I
10.1038/s41598-020-67745-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The properties of cytosine- and guanine-rich oligonucleotides contributed to employing them as sensing elements in various biosensors. In this paper, we report our current development of fluorescence oligonucleotide probes based on i-motif or G-quadruplex forming oligonucleotides for cellular measurements or bioimaging applications. Additionally, we also focus on the spectral properties of the new fluorescent silver nanoclusters based system (ChONC12-AgNCs) that is able to anchor at the Langmuir monolayer interface, which is mimicking the surface of living cells membrane.
引用
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页数:13
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