Personalized Approach in Treatment of Neovascular Age-Related Macular Degeneration

Background: Age-related macular degeneration (AMD) is a progressive, degenerative disease of the central retina. AMD is subdivided into "dry" (atrophic), "wet" (exudative), and neovascular (nAMD) forms. In recent years, the concepts about nAMD changed with the development of optical coherence tomography-angiography (OCT-A) and intravitreal anti-VEGF treatment. The aim of this study was to define the morphologic type of the neovascular membrane (NVM) before treatment with OCT-A and to register vascular remodeling after treatment with anti-VEGF. We also analyzed the relationship between NVM and visual acuity. Methods: The study was retrospective and included 119 patients with newly diagnosed, treatment-naive nAMD. All the patients underwent full ophthalmic examination and also fluoresceine angiography and optical coherence tomography-angiography (OCT-A). Results: Based on the collected data, we found repetitive regularities. Conclusion: The analysis of our results could be used as prognostic markers for the evolution of the disease and as a basis for new treatment strategies, depending on the naive NVM morphologic type.