RETRACTED: Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial (Publication with Expression of Concern. See vol. 6, pg. 763, 2018) (Retracted article. See vol. 7, pg. 334, 2019)

被引:102
|
作者
Estruch, Ramon [1 ,4 ]
Angel Martinez-Gonzalez, Miguel [1 ,5 ]
Corella, Dolores [1 ,6 ]
Salas-Salvado, Jordi [1 ,7 ]
Fito, Montserrat [1 ,8 ]
Chiva-Blanch, Gemma [4 ]
Fiol, Miquel [1 ,9 ,10 ]
Gomez-Gracia, Enrique [1 ,11 ]
Aros, Fernando [1 ,12 ]
Lapetra, Jose [1 ,13 ]
Serra-Majem, Lluis [1 ,14 ,15 ]
Pinto, Xavier [1 ,16 ]
Buil-Cosiales, Pilar [1 ,22 ]
Sorli, Jose V. [1 ,6 ,17 ]
Munoz, Miguel A. [18 ,19 ]
Basora-Gallisa, Josep [1 ,20 ,21 ]
Maria Lamuela-Raventos, Rosa [1 ,23 ]
Serra-Mir, Merce [1 ,2 ,3 ]
Ros, Emilio [1 ,2 ,3 ]
机构
[1] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
[2] Univ Barcelona, Dept Internal Med, Barcelona, Spain
[3] Univ Barcelona, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain
[4] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer, Barcelona, Spain
[5] Univ Navarra, Inst Hlth Res Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain
[6] Univ Valencia, Sch Med, Dept Prevent Med, Valencia, Spain
[7] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Hosp Univ St Joan, Dept Human Nutr, Reus, Spain
[8] Hosp Mar, Inst Recerca, Cardiovasc & Nutr Res Grp, Barcelona, Spain
[9] Univ Balearic Isl, Inst Hlth Sci, Palma De Mallorca, Spain
[10] Hosp Son Espases, Palma De Mallorca, Spain
[11] Univ Malaga, Dept Prevent Med, Malaga, Spain
[12] Univ Hosp Alava, Dept Cardiol, Vitoria, Spain
[13] San Pablo Hlth Ctr, Primary Care Div Sevilla, Dept Family Med, Seville, Spain
[14] Univ Las Palmas Gran Canaria, Res Inst Biomed Res & Hlth Serv, Las Palmas Gran Canaria, Spain
[15] Univ Las Palmas Gran Canaria, Sch Med, Las Palmas Gran Canaria, Spain
[16] Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Lhospitalet De Llobregat, Spain
[17] Valencia Inst Hlth, Primary Care Div, Valencia, Spain
[18] Inst Catala Salut, Primary Hlth Care Div, Barcelona, Spain
[19] Idiap Jordi Gol, Barcelona, Spain
[20] Inst Catala Salut, Primary Hlth Care Div, Tarragona, Spain
[21] Idiap Jordi Gol, Tarragona, Spain
[22] Inst Hlth Res Navarra, Primary Hlth Care Div, Pamplona, Spain
[23] Univ Barcelona, Xarxa Referencia Tecnol Aliments, Inst Invest Alimentac & Seguridad Alimentaria, Dept Nutr & Bromatol,Sch Pharm, Barcelona, Spain
来源
LANCET DIABETES & ENDOCRINOLOGY | 2016年 / 4卷 / 08期
关键词
WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; LOW-CARBOHYDRATE; PREVENTION; GUIDELINES; ADULTS; RISK; MEN; QUESTIONNAIRE; ADHERENCE;
D O I
10.1016/S2213-8587(16)30085-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese. Methods PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. 7447 asymptomatic men (aged 55-80 years) and women (aged 60-80 years) who had type 2 diabetes or three or more cardiovascular risk factors were randomly assigned (1: 1: 1) with a computer-generated number sequence to one of three interventions: Mediterranean diet supplemented with extra-virgin olive oil (n=2543); Mediterranean diet supplemented with nuts (n=2454); or a control diet (advice to reduce dietary fat; n=2450). Energy restriction was not advised, nor was physical activity promoted. In this analysis of the trial, we measured bodyweight and waist circumference at baseline and yearly for 5 years in the intention-to-treat population. The PREDIMED trial is registered with ISRCTN.com, number ISRCTN35739639. Findings After a median 4.8 years (IQR 2.8-5.8) of follow-up, participants in all three groups had marginally reduced bodyweight and increased waist circumference. The adjusted difference in 5 year changes in bodyweight in the Mediterranean diet with olive oil group was -0.43 kg (95% CI -0.86 to -0.01; p=0.044) and in the nut group was -0.08 kg (-0.50 to 0.35; p=0.730), compared with the control group. The adjusted difference in 5 year changes in waist circumference was -0.55 cm (-1.16 to -0.06; p=0.048) in the Mediterranean diet with olive oil group and -0.94 cm (-1.60 to -0.27; p=0.006) in the nut group, compared with the control group. Interpretation A long-term intervention with an unrestricted-calorie, high-vegetable-fat Mediterranean diet was associated with decreases in bodyweight and less gain in central adiposity compared with a control diet. These results lend support to advice not restricting intake of healthy fats for bodyweight maintenance.
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页码:666 / 676
页数:11
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