Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus

被引：114
|
作者：
Ye, Jin [1 ]
机构：
[1] Univ Texas, Southwestern Med Ctr, Dept Mol Genet, Dallas, TX 75230 USA
来源：
PLOS PATHOGENS | 2007年 / 3卷 / 08期
关键词：
D O I：
10.1371/journal.ppat.0030108
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.
引用
收藏
页码：1017 / 1022
页数：6
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