Dishevelled: linking convergent extension with neural tube closure

被引：44
|
作者：
Copp, AJ [1 ]
Greene, NDE
Murdoch, JN
机构：
[1] UCL, Inst Child Hlth, Neural Dev Unit, London WC1N 1EH, England
[2] MRC, Mammalian Genet Unit, Didcot OX11 0RD, Oxon, England
来源：
TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 09期
关键词：
D O I：
10.1016/S0166-2236(03)00212-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart and cannot achieve the apposition necessary for neural tube closure.
引用
收藏
页码：453 / 455
页数：3
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