Controllable Preparation of Ag-Au Bimetallic Nanotubes for Non-invasive Detection of Glucose in Sweat

Real-time monitoring of blood glucose levels is of great significance for the diagnosis and treatment of diabetic patients. However, traditional enzymatic minimally invasive determinations have problems such as low stability and poor experience. By using silver nanowires as a template, high-quality Ag-Au bimetallic nanotubes (Ag-Au BMNTs/GCE) could be successfully prepared by a one-step Galvanic replacement reaction to realize the non-enzymatic and non-invasive measurement of glucose. By optimizing the content of HAuCl4, the morphology and composition of Ag-Au bimetallic nanotubes could be controlled. The research results showed that the Ag-Au BMNTs/GCE had a wide detection range for glucose detection (1 mu mol/L-3.79 mmol/L, 3.79 mmol/L - 13.79 mmol/L), high sensitivity (154.09 mu A/(mmol/L), 60.77 mu A/(mmol/L)) and low detection limit (1 mu mol/L). At the same time, the sensor showed good anti-interference performance and stability, and was successfully applied to the accurate determination of glucose content in human sweat, which indicated that the electrochemical sensor based on Ag-Au BMNTs had potential application value in the field of non-enzyme and non-invasive blood glucose detection.