What can development teach us about menopause?

被引：8

作者：

McCarthy, Margaret M. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA

来源：

BRAIN RESEARCH | 2011年 / 1379卷

关键词：

Estradiol; Neurogenesis; Synaptogenesis; GABA; Glutamate; Sex differences; CATION-CHLORIDE COTRANSPORTERS; DENDRITIC SPINE DENSITY; CA1 PYRAMIDAL CELLS; SEXUAL-DIFFERENTIATION; HIPPOCAMPAL-NEURONS; RAT HIPPOCAMPUS; MESSENGER-RNA; ESTRADIOL INCREASES; ESTROGEN-RECEPTORS; COGNITIVE FUNCTION;

D O I：

10.1016/j.brainres.2010.11.094

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by a sensitive period of hormone responsiveness, and in both cases, the neurotransmitters GABA and glutamate, as well as synaptogenesis and cell proliferation are major hormone targets. This review compares and contrasts the effects of estradiol on the developing and aging brain and highlights new avenues of exploration and therapeutic development. (C) 2010 Published by Elsevier B.V.

引用

页码：109 / 118

页数：10

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