The purpose of the present study was to evaluate the effects of silane primers with and without heat treatment on bonding between a resin and a leucite-reinforced ceramic (GN-Ceram). Six dental primers (GC Ceramic Primer, GP; Clearfil Ceramic Primer, CP; RelyX Ceramic Primer, RP; Tokuso Ceramic Primer, TP; Shofu Porcelain Primer, SP; and Porcelain Liner M, PM) and five experimental primers (MDS, MTS, MDES, MTES, and ATS) were evaluated. GN-Ceram specimen was primed, heated at 100 C for 60 min (Heat), and then bonded to a resin composite using a self-curing resin. Shear bond testing revealed that GP, GP/Heat, CP, CP/Heat, RP, RP/Heat, TP, TP/Heat, SP, SP/Heat, PM, PM/Heat, MDS/Heat, MTS, MTS/Heat, and ATS/Heat exhibited superior bond strengths. No-primer, No-primer/Heat, MDS, MDES, MTES, and ATS exhibited low bond strengths, while there were no significant differences in bond strength among SP, MDS, MDES/Heat, and MTES/Heat. It seemed that heat treatment improved the bonding performance for MDS, MTES, and ATS only.