ATP Dependent Efflux Transporters ABCB1 and ABCG2 Are Unlikely to Impact the Efficacy, or Mediate Resistance to the Tyrosine Kinase Inhibitor, Ponatinib

被引：0
|
作者：
White, Deborah L. [1 ]
Lu, Liu [1 ]
Clackson, Timothy P. [3 ]
Saunders, Verity A. [2 ]
Hughes, Timothy P. [4 ]
机构：
[1] Univ Adelaide, Dept Med, Adelaide, SA 5001, Australia
[2] Ctr Canc Biol SA Pathol RAH Site, Dept Haematol, Adelaide, SA, Australia
[3] ARIAD Pharmaceut, Adelaide, SA, Australia
[4] Univ Adelaide, Ctr Personalised Canc Med, Adelaide, SA, Australia
来源：
BLOOD | 2011年 / 118卷 / 21期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1180 / 1180
页数：1
相关论文
共 50 条
  • [1] Multispecificity of drug transporters: Probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2
    Cramer, Joerg
    Kopp, Stephan
    Bates, Susan E.
    Chiba, Peter
    Ecker, Gerhard F.
    CHEMMEDCHEM, 2007, 2 (12) : 1783 - 1788
  • [2] Interaction of the Efflux Transporters ABCB1 and ABCG2 With Imatinib, Nilotinib, and Dasatinib
    Eadie, L. N.
    Hughes, T. P.
    White, D. L.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (03) : 294 - 306
  • [3] Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters
    Awortwe, Charles
    Bruckmueller, Henrike
    Kaehler, Meike
    Cascorbi, Ingolf
    MOLECULAR PHARMACEUTICS, 2021, 18 (04) : 1622 - 1633
  • [4] Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice
    Song, Yoo-Kyung
    Kim, Min-Ju
    Kim, Min-Soo
    Lee, Ji Hun
    Chung, Suk-Jae
    Song, Jin Sook
    Chae, Yoon-Jee
    Lee, Kyeong-Ryoon
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 173
  • [5] Foretinib, a c-MET receptor tyrosine kinase inhibitor, tackles multidrug resistance in cancer cells by inhibiting ABCB1 and ABCG2 transporters
    Nazari, Somayeh
    Mosaffa, Fatemeh
    Poustforoosh, Alireza
    Mortazavi, Motahareh
    Saso, Luciano
    Firuzi, Omidreza
    Moosavi, Fatemeh
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2024, 484
  • [6] The Allosteric Inhibitor ABL001 Is Susceptible to Resistance in Vitro Mediated By Overexpression of the Drug Efflux Transporters ABCB1 and ABCG2
    Eadie, Laura N.
    Saunders, Verity A.
    Leclercq, Tamara M.
    Branford, Susan
    White, Deborah L.
    Hughes, Timothy P.
    BLOOD, 2015, 126 (23)
  • [7] Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478
    Shi, Zhi
    Tiwari, Amit K.
    Shukla, Suneet
    Robey, Robert W.
    Kim, In-Wha
    Parmar, Smitaben
    Bates, Susan E.
    Si, Qiu-Sheng
    Goldblatt, Curtis S.
    Abraham, Ioana
    Fu, Li-Wu
    Ambudkar, Suresh V.
    Chen, Zhe-Sheng
    BIOCHEMICAL PHARMACOLOGY, 2009, 77 (05) : 781 - 793
  • [8] Lipid Regulation of the ABCB1 and ABCG2 Multidrug Transporters
    Hegedus, Csilla
    Telbisz, Agnes
    Hegedus, Tamas
    Sarkadi, Balazs
    Ozvegy-Laczka, Csilla
    ABC TRANSPORTERS AND CANCER, 2015, 125 : 97 - 137
  • [9] Efflux transporters in ulcerative colitis:: Decreased expression of BCRP (ABCG2) and Pgp (ABCB1)
    Englund, Gunilla
    Jacobson, Annica
    Rorsmon, Fredrik
    Artursson, Per
    Kindmark, Andreas
    Ronnblom, Anders
    INFLAMMATORY BOWEL DISEASES, 2007, 13 (03) : 291 - 297
  • [10] Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters
    Zhang, Yun-Kai
    Zhang, Guan-Nan
    Wang, Yi-Jun
    Patel, Bhargav A.
    Talele, Tanaji T.
    Yang, Dong-Hua
    Chen, Zhe-Sheng
    SCIENTIFIC REPORTS, 2016, 6
12345