Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes?

被引：131
|
作者：
Kusari, Souvik [1 ]
Spiteller, Michael [1 ]
机构：
[1] TU Dortmund, Chair Environm Chem & Analyt Chem, Fac Chem, Inst Environm Res INFU, D-44221 Dortmund, Germany
来源：
NATURAL PRODUCT REPORTS | 2011年 / 28卷 / 07期
关键词：
HORIZONTAL GENE-TRANSFER; HYPERICUM-PERFORATUM; NATURAL-PRODUCTS; DRUG DISCOVERY; FUNGUS; PODOPHYLLOTOXIN; MICROORGANISMS; BIOSYNTHESIS; BIODIVERSITY; DIVERSITY;
D O I：
10.1039/c1np00030f
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The prospect of endophytes capable of producing associated plant natural products with therapeutic potential is undeniable. However, the unyielding struggle so far to transform these potential sources into sustainable microbial manufacturers on a commercial scale has been disappointing. In this Viewpoint, we address this trade-off between endophyte discovery and viable industrial application.
引用
收藏
页码：1203 / 1207
页数：5
相关论文
共 50 条
  • [1] Endophytes as in vitro production platforms of high value plant secondary metabolites
    Venugopalan, Aarthi
    Srivastava, Smita
    BIOTECHNOLOGY ADVANCES, 2015, 33 (06) : 873 - 887
  • [2] Bioactive Secondary Metabolites Produced by the Fungal Endophytes of Conifers
    Stierle, Andrea A.
    Stierle, Donald B.
    NATURAL PRODUCT COMMUNICATIONS, 2015, 10 (10) : 1671 - 1682
  • [3] Fungal endophytes - secret producers of bioactive plant metabolites
    Aly, A. H.
    Debbab, A.
    Proksch, P.
    PHARMAZIE, 2013, 68 (07): : 499 - 505
  • [4] Plant endophytes: Secondary metabolites and biological activities
    dos Santos, Gustavo Souza
    FITOTERAPIA, 2025, 182
  • [5] Bioactive secondary metabolites from endophytes and associated marine derived fungi
    Debbab, Abdessamad
    Aly, Amal H.
    Proksch, Peter
    FUNGAL DIVERSITY, 2011, 49 (01) : 1 - 12
  • [6] Bioactive secondary metabolites from endophytes and associated marine derived fungi
    Abdessamad Debbab
    Amal H. Aly
    Peter Proksch
    Fungal Diversity, 2011, 49 : 1 - 12
  • [7] How and why do endophytes produce plant secondary metabolites?
    Naik, Sachin
    Shaanker, Ramanan Uma
    Ravikanth, Gudasalamani
    Dayanandan, Selvadurai
    SYMBIOSIS, 2019, 78 (03) : 193 - 201
  • [8] Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook
    Christoph Wawrosch
    Sergey B. Zotchev
    Applied Microbiology and Biotechnology, 2021, 105 : 6649 - 6668
  • [9] How and why do endophytes produce plant secondary metabolites?
    Sachin Naik
    Ramanan Uma Shaanker
    Gudasalamani Ravikanth
    Selvadurai Dayanandan
    Symbiosis, 2019, 78 : 193 - 201
  • [10] Prospecting potential of endophytes for modulation of biosynthesis of therapeutic bioactive secondary metabolites and plant growth promotion of medicinal and aromatic plants
    Devendra Singh
    Shobit Thapa
    Himanshu Mahawar
    Dharmendra Kumar
    Neelam Geat
    S. K. Singh
    Antonie van Leeuwenhoek, 2022, 115 : 699 - 730
12345