Effect of 28-day exposure to fenpropathrin on the activities of serum alanine transaminase and liver antioxidant enzymes in mice

Fenpropathrin (FEN) as administered intraperitoneally in doses of 2.38 mg/kg, 5.9 5mg/kg, or 11.9 mg/kg bk. to mice for 28 consecutke dais. FEN did not significantly affect the activit) of alanine transaminase (ALT) in the sera. Superoxide dismutase and glutathione peroxidase activities were significantly elevated in the liver after a 28-d exposure to moderate or highest doses of the pesticide. These results demonstrate that the 28-da) exposure to FEN leads to an up-regulation of expression of antioxidant enz)mes in response to an oxidatke stress in mouse lk er ithout causing a significant increase in actkik.