Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried blaNDM-1

被引：1

作者：

Sakamoto, Noriko ^{[1
]}

Akeda, Yukihiro ^{[1
,2
,3
]}

Sugawara, Yo ^{[1
]}

Takeuchi, Dan ^{[1
]}

Motooka, Daisuke ^{[4
]}

Yamamoto, Norihisa ^{[1
,2
,3
]}

Laolerd, Warawut ^{[5
]}

Santanirand, Pitak ^{[5
]}

Hamada, Shigeyuki ^{[1
]}

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Japan Thailand Res Collaborat Ctr Infect Dis, Osaka, Japan

[2] Osaka Univ, Osaka Univ Hosp, Div Infect Control & Prevent, Osaka, Japan

[3] Osaka Univ, Grad Sch Med, Dept Infect Control & Prevent, Osaka, Japan

[4] Osaka Univ, Microbial Dis Res Inst, Genome Informat Ctr, Dept Infect Metagen, Osaka, Japan

[5] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok, Thailand

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 12期

关键词：

IS5; Klebsiella pneumoniae; Tn3; beta-lactamases; bla(NDM); carbapenemase; producing Enterobacteriaceae; carbapenems;

D O I：

10.1128/AAC.01520-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report here Klebsiella pneumoniae strains carrying chromosomal bla(NDM-1) in Thailand. The genomes of these two isolates include a 160-kbp insertion containing bla(NDM-1), which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of bla(NDM-1) into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.

引用

页数：6

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