Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases

被引：15

作者：

Shodeinde, Aaliyah B. ^{[1
,2
]}

Murphy, Andrew C. ^{[1
,2
]}

Oldenkamp, Heidi F. ^{[1
,2
]}

Potdar, Abhishek S. ^{[3
]}

Ludolph, Catherine M. ^{[1
]}

Peppas, Nicholas A. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] McKetta Dept Chem Engn, 200 E Dean Keeton St,Stop C0400, Austin, TX 78712 USA

[2] Univ Texas Austin, Inst Biomat Drug Delivery & Regenerat Med, 107 W Dean Keeton St,Stop C0800, Austin, TX 78712 USA

[3] Univ Texas Austin, Dept Biomed Engn, 107 W Dean Keeton St,Stop C0800, Austin, TX 78712 USA

[4] Univ Texas Austin, Coll Pharm, Div Mol Pharmaceut & Drug Delivery, 2409 Univ Ave,Stop A1900, Austin, TX 78712 USA

[5] Dell Med Sch, Dept Surg & Perioperat Care, 1601 Trinity St,Bldg B,Stop Z0800, Austin, TX 78712 USA

[6] Dell Med Sch, Dept Pediat, 1400 Barbara Jordan Blvd, Austin, TX 78723 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2020年 / 30卷 / 37期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

biomaterials; drug delivery; polymeric materials; sensors; biosensing; stimuli-responsive materials; tissue engineering; REFRACTIVE-INDEX SENSITIVITY; LABEL-FREE DETECTION; C-REACTIVE PROTEIN; MULTIPLE-SCLEROSIS; RHEUMATOID-ARTHRITIS; DRUG-DELIVERY; TNF-ALPHA; ORAL DELIVERY; CEREBROSPINAL-FLUID; GOLD NANOPARTICLES;

D O I：

10.1002/adfm.201909556

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Autoimmune diseases are a group of debilitating illnesses that are often idiopathic in nature. The steady rise in the prevalence of these conditions warrants new approaches for diagnosis and treatment. Stimuli-responsive biomaterials also known as "smart," "intelligent," or "recognitive" biomaterials are widely studied for their applications in drug delivery, biosensing, and tissue engineering due to their ability to produce thermal, optical, chemical, or structural changes upon interacting with the biological environment. Studies within the last decade that harness the recognitive capabilities of these biomaterials toward the development of novel detection and treatment options for autoimmune diseases are critically analyzed.

引用

页数：22

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