Control of Regulatory T Cells by Co-signal Molecules

被引：23

作者：

Wing, James Badger ^{[1
]}

Tay, Christopher ^{[1
]}

Sakaguchi, Shimon ^{[1
,2
]}

机构：

[1] Osaka Univ, WPI Immunol Frontier Res Ctr IFReC, Expt Immunol Lab, Osaka, Japan

[2] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto, Japan

来源：

CO-SIGNAL MOLECULES IN T CELL ACTIVATION: IMMUNE REGULATION IN HEALTH AND DISEASE | 2019年 / 1189卷

关键词：

Tregs; CTLA-4; PD-1; CD28; OX40; GITR; CD27; CD30; TIGIT; DR3; TNFR2; ICOS; Tim-3; TNF RECEPTOR SUPERFAMILY; CUTTING EDGE; AUTOIMMUNE-DISEASE; IMMUNE-RESPONSES; ALLOGRAFT-REJECTION; LIGAND INTERACTION; EFFECTOR FUNCTION; DENDRITIC CELLS; SELF-TOLERANCE; IN-VITRO;

D O I：

10.1007/978-981-32-9717-3_7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.

引用

页码：179 / 210

页数：32

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