Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans

被引：31

作者：

Okabe, Miki ^{[1
]}

Sugita, Takashi ^{[2
]}

Kinoshita, Kaoru ^{[1
]}

Koyama, Kiyotaka ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan

[2] Meiji Pharmaceut Univ, Dept Microbiol, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 04期

关键词：

PF1163A;

D O I：

10.1021/acs.jnatprod.6b00019

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new 13-membered macrolides (1, 7), along with known 13-membered macrolides PF1163A, B, D, H, and F (2-6), were isolated from a strain of a marine-derived fungus, Penicillium meleagrinum var. viridiflavum. The structures of 1 and 7 were elucidated from spectroscopic data (NMR, MS, IR). Compounds 1-7 showed synergistic effects with fluconazole against azole-resistant Candida albicans by a checkerboard assay.

引用

页码：1208 / 1212

页数：5

共 4 条

[1] ANTIFUNGAL COMPOUND AGAINST AZOLE-RESISTANT CANDIDA ALBICANS FROM A MARINE-DERIVED FUNGUS, PARABOEREMIA SELAGINELLAE
Yamaguchi, Eri
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HETEROCYCLES, 2020, 100 (04) : 645 - 652
[2] Pyridone Alkaloids from a Marine-Derived Fungus, Stagonosporopsis cucurbitacearum, and Their Activities against Azole-Resistant Candida albicans
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[3] Potent synergistic effect of natural product-inspired Sinomenine derivatives with fluconazole against azole-resistant Candida albicans
Liu, Wei
Du, Jiayao
Qin, Zhenzhen
Zhao, Mei
Du, Shuaibo
Xie, Jianwu
Zhang, Ya
Wang, Mengzhou
Wang, Shengzheng
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 121
[4] Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
Yan, Zhimin
Hua, Hong
Xu, Yanying
Samaranayake, Lakshman P.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 2012

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