Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis?

被引：57
|
作者：
Tecer, Duygu [1 ]
Sezgin, Melek [2 ]
Kanik, Arzu [3 ]
Incel, Nurgul Arinci [2 ]
Cimen, Ozlem Bolgen [2 ]
Bicer, Ali [2 ]
Sahin, Gunsah [2 ]
机构：
[1] Gazi Univ, Div Rheumatol, Dept Phys Med & Rehabil, Fac Med, Ankara, Turkey
[2] Mersin Univ, Dept Phys Med & Rehabil Mersin, Fac Med, Mersin, Turkey
[3] Mersin Univ, Fac Med, Dept Biostat & Med Informat, Mersin, Turkey
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 09期
关键词：
C-reactive protein; Disease Activity Score 28; erythrocyte sedimentation rate; mean platelet volume; red cell distribution width; rheumatoid arthritis; INFLAMMATORY-BOWEL-DISEASE; FAMILIAL MEDITERRANEAN FEVER; PROGNOSTIC MARKER; HEART-FAILURE; PREDICTOR; ERYTHROPOIESIS; ASSOCIATION; BIOMARKERS; MORTALITY; INDICATOR;
D O I：
10.2217/bmm-2016-0148
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To evaluate the relationship between mean platelet volume (MPV) and red cell distribution width (RDW), and disease activity in rheumatoid arthritis (RA). Patients & methods: Hundred RA and 100 controls were included. Results: MPV and RDW were higher in RA (p < 0.0001). The cut-off levels of RDW and MPV were 14.8 and 10.4. Patients with RDW >14.8 had higher Disease Activity Score 28 (DAS28; p = 0.002) and pain score (p = 0.0007). RDW was positively correlated with DAS28 and pain. But, DAS28 and pain were not different between patients with MPV >10.4 and <10.4. Conclusion: MPV and RDW were significantly higher in RA. RDW and MPV were similar to erythrocyte sedimentation rate and C-reactive protein to indicate inflammatory activity. RDW was correlated with pain and DAS28, but MPV was not associated with them.
引用
收藏
页码：967 / 974
页数：8
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