Toward Concurrent Testing for Somatic and Germline Variants in Cancer Patients

被引：1

作者：

Mandelker, Diana ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1250 First Ave,Schwartz Bldg S-901a, New York, NY 10065 USA

来源：

CLINICAL CANCER RESEARCH | 2016年 / 22卷 / 16期

关键词：

D O I：

10.1158/1078-0432.CCR-16-1043

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sequencing for somatic alterations in patients' tumors is being increasingly clinically implemented to detect mutations that may guide therapy. Germline analysis of a cohort of patients undergoing tumor sequencing with matched normal has revealed that a small but significant percentage of these patients have germline variants that confer cancer susceptibility. (C) 2016 AACR.

引用

页码：3987 / 3988

页数：2

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