Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease

被引：47

作者：

Mei, Dan ^{[1
]}

Tan, W. S. Daniel ^{[1
]}

Tay, Yvonne ^{[2
,3
]}

Mukhopadhyay, Amartya ^{[4
]}

Wong, W. S. Fred ^{[1
,5
,6
]}

机构：

[1] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

[2] Natl Univ Singapore, Canc Sci Inst Singapore, Ctr Translat Med, Singapore 117599, Singapore

[3] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

[4] Natl Univ Hlth Syst, Univ Med Cluster, Resp & Crit Care Med, Singapore 119228, Singapore

[5] Natl Univ Singapore, Immunol Program, Life Sci Inst, Singapore 117456, Singapore

[6] Natl Univ Singapore, Singapore HUJ Alliance Res & Enterprise, Singapore 138602, Singapore

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

ANTISENSE OLIGONUCLEOTIDES; IN-VIVO; COPD; INFLAMMATION; DELIVERY; PATHOGENESIS; PROTECTS; VERSICAN; SMOKERS; ASTHMA;

D O I：

10.1016/j.tips.2020.04.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation with persistent respiratory symptoms. Current therapeutics for COPD are largely borrowed from the drug armamentarium for the treatment of asthma, which has different pathophysiological mechanisms from COPD. COPD has been linked to dysregulated expression of mRNAs and noncoding (nc)RNAs including miRNAs, PIWI-interacting (pi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs. This review highlights and discusses some recent advances towards development of RNA therapeutics for COPD.

引用

页码：475 / 486

页数：12

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