Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

被引：11

作者：

Navratilova, E

Eaton, MC

Stropova, D

Varga, EV

Vanderah, TW

Roeske, WR

Yamamura, HI ^{[1
]}

机构：

[1] Univ Arizona, Coll Med, Hlth Sci Ctr, Dept Med Pharmacol, Tucson, AZ 85724 USA

[2] Univ Arizona, Dept Biochem & Mol Biophys, Tucson, AZ 85724 USA

[3] Univ Arizona, Dept Psychiat, Tucson, AZ 85724 USA

[4] Univ Arizona, Dept Med, Tucson, AZ 85724 USA

[5] Univ Arizona, BIO5 Inst, Tucson, AZ 85724 USA

[6] Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 519卷 / 03期

基金：

美国国家卫生研究院;

关键词：

delta-opioid receptor; morphine; receptor phosphorylation;

D O I：

10.1016/j.ejphar.2005.07.024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S-363 in the C-terminus of the human delta-opioid receptor. Morphine-mediated phosphorylation reached 53 +/- 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S-363 may contribute to delta-opioid receptor desensitization by morphine. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：212 / 214

页数：3

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