ANDROGEN EXCESS AS A MAJOR DETERMINANT OF CARDIOVASCULAR RISK IN WOMEN: EVIDENCE FROM THE POLYCYSTIC OVARY SYNDROME

被引：4
|
作者：
Pepene, C. E. Georgescu [1 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Cty Cluj Emergency Clin Hosp, Endocrinol Clin, Cluj Napoca 400349, Romania
来源：
ACTA ENDOCRINOLOGICA-BUCHAREST | 2011年 / 7卷 / 04期
关键词：
polycystic ovary syndrome; testosterone; endothelial dysfunction; adipocytokine; visfatin; osteoprotegerin; insulin; INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; RECEPTOR GENE; SYNDROME PCOS; SEX-HORMONES; OSTEOPROTEGERIN; TESTOSTERONE; MORTALITY; DYSFUNCTION; DISEASE;
D O I：
10.4183/aeb.2011.529
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Apart from endocrine and reproductive disturbances, polycystic ovary syndrome (PCOS) clusters several cardiovascular risk factors, mainly insulin resistance, obesity and dyslipidemia. In addition, androgen excess significantly contributes to enhanced vascular risk. Several mediators of endothelial dysfunction have been characterized lately in patients with PCOS, emerging as independent predictors of vascular abnormalities and potentially useful biomarkers of endothelial impairment in PCOS.
引用
收藏
页码：529 / 533
页数：5
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