Design, Synthesis, and Anti-Proliferative Activity of Quinoxaline Linked 1,2,4-Oxadiazole Hybrids

被引：4
|
作者：
Badithapuram, Vinitha [1 ]
Nukala, Satheesh Kumar [1 ]
Thirukovela, Narasimha Swamy [1 ]
Manchal, Ravinder [1 ]
Dasari, Gouthami [1 ]
Bandari, Srinivas [1 ]
机构：
[1] Chaitanya Deemed Univ, Dept Chem, Warangal 506001, Andhra Pradesh, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 01期
关键词：
quinoxaline-1; 2; 4-oxadiazole; in vitro anticancer activity; molecular docking studies; in vitro tyrosine kinase EGFR inhibitory activity; SAR studies; POTENTIAL ANTICANCER; DERIVATIVES; PHIDIANIDINE; DISCOVERY;
D O I：
10.1134/S1070363222010169
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, synthesis of some new quinoxaline-1,2,4-oxadiazole derivatives is presented, and their in vitro anti-cancer activity against four human cancer cell lines like MCF-7 (human breast), HeLa (human cervical), HCT116 (human colon carcinoma) HepG2 (liver hepato cellular carcinoma) is tested. The results reveal promising results for four products. One of the products displays higher activity against all tested cell lines than the standard drug etoposide. Molecular docking studies of the products on EGFR receptor suggest that the most potent compound strongly binds to protein EGFR (pdbid: 4HJO). Two compounds exhibit promising inhibitory activity of tyrosine kinase EGFR.
引用
收藏
页码：117 / 124
页数：8
相关论文
共 50 条
  • [1] Design, Synthesis, and Anti-Proliferative Activity of Quinoxaline Linked 1,2,4-Oxadiazole Hybrids
    Vinitha Badithapuram
    Satheesh Kumar Nukala
    Narasimha Swamy Thirukovela
    Ravinder Manchal
    Gouthami Dasari
    Srinivas Bandari
    Russian Journal of General Chemistry, 2022, 92 : 117 - 124
  • [2] Design, Synthesis, and Anti-Proliferative Activity of Some New Quinoxaline-1,3,4-oxadiazole Sulfonamide Hybrids
    Sharada Ravula
    Satheesh Kumar Nukala
    Narasimha Swamy Thirukovela
    Narsimha Sirassu
    Gouthami Dasari
    Srimathi Kurma
    Srinivas Bandari
    Russian Journal of General Chemistry, 2022, 92 : 702 - 708
  • [3] Design, Synthesis, and Anti-Proliferative Activity of Some New Quinoxaline-1,3,4-oxadiazole Sulfonamide Hybrids
    Ravula, Sharada
    Nukala, Satheesh Kumar
    Thirukovela, Narasimha Swamy
    Sirassu, Narsimha
    Dasari, Gouthami
    Kurma, Srimathi
    Bandari, Srinivas
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (04) : 702 - 708
  • [4] Design, Synthesis, and Anti-Proliferative Activity of Some New Quinoxaline Containing 1,2,4-Thiadiazoles Amide Hybrids
    Srimathi Kurma
    Gouthami Dasari
    Satheesh Kumar Nukala
    Sharada Ravula
    Padma Kandukuri
    Srinivas Bandari
    Russian Journal of General Chemistry, 2022, 92 : 1326 - 1332
  • [5] Design, Synthesis, and Anti-Proliferative Activity of Some New Quinoxaline Containing 1,2,4-Thiadiazoles Amide Hybrids
    Kurma, Srimathi
    Dasari, Gouthami
    Nukala, Satheesh Kumar
    Ravula, Sharada
    Kandukuri, Padma
    Bandari, Srinivas
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (07) : 1326 - 1332
  • [6] Design, synthesis and molecular docking studies of new Quinoxaline-linked-1,2,4-triazole-Sulfonamide hybrids as Anti-proliferative agents
    Reddy, Nallapu Malla
    Vadluri, Rajender
    Arasan, Jeyanthi
    CHEMICAL BIOLOGY LETTERS, 2022, 9 (04):
  • [7] Design, synthesis and anti-fungal activity of 1,2,4-oxadiazole derivatives
    Wang F.
    Chen Y.
    Pei H.
    Liu D.
    Zhang J.
    Zhang L.
    Huagong Xuebao/CIESC Journal, 2023, 74 (03): : 1390 - 1398
  • [8] Indole-3-carbinol and 1,3,4-Oxadiazole Hybrids: Synthesis and Study of Anti-Proliferative and Anti-Microbial Activity
    Gokhale, Nikhila
    Panathur, Naveen
    Dalimba, Udayakumar
    Kumsi, Manjunatha
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2015, 68 (10) : 1603 - 1613
  • [9] Design and Synthesis of Some New Quinoxaline Containing 1,3,4-Oxadiazole Hybrids and Evaluation of Their Anti-Cancer Activity
    Kandukuri, Padma
    Dasari, Gouthami
    Nukala, Satheesh Kumar
    Bandari, Srinivas
    Juluru, Bhaskar
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2023, 49 (01) : 139 - 146
  • [10] Design and Synthesis of Some New Quinoxaline Containing 1,3,4-Oxadiazole Hybrids and Evaluation of Their Anti-Cancer Activity
    Padma Kandukuri
    Gouthami Dasari
    Satheesh Kumar Nukala
    Srinivas Bandari
    Bhaskar Juluru
    Russian Journal of Bioorganic Chemistry, 2023, 49 : 139 - 146
12345