Determination of bisphenol A in canned marine products by solid-phase extraction and gas chromatography-mass spectrometry

An analytical method was developed for determining bisphenol A (BPA) in canned marine products. A sample was extracted with ethyl acetate and the organic phase was dehydrated through a graphite carbon-anhydrous sodium sulfate column. After defatting by n-hexane/acetonitrile partition, the acetonitrile phase was evaporated and cleaned up on a polystyrene solid-phase cartridge (GL-Pak PLS-2). BPA was determined by GC,;R;IS (SIM) after trimethylsilylation. The recovery of BPA from 20 g of canned boiled mackerel containing 2 mug of BPA was 93.4 +/-2.5% (n = 3), and the sensitivity limit of this quantification was about 10 ng/g. We then analyzed BPA in 14 samples of canned marine products by this method. BPA was detected in the range of 21.1 ng/g similar to 134.8ng/g in 8 samples. This method should be useful as an analytical method of BPA in canned marine products, due to its simplicity of use and selectivity.