Brain metabolic differences between sporadic and familial Alzheimer's disease

被引：25

作者：

Mosconi, L

Sorbi, S

Nacmias, B

De Cristofaro, MTR

Fayyaz, M

Cellini, E

Bagnoli, S

Bracco, L

Herholz, K

Pupi, A

机构：

[1] Univ Florence, Dept Clin Pathophysiol, Nucl Med Unit, I-50134 Florence, Italy

[2] Univ Florence, Dept Neurol & Psychiat Sci, I-50134 Florence, Italy

[3] Univ Cologne, Neurol Clin, Cologne, Germany

[4] Max Planck Inst Neurol Res, Cologne, Germany

来源：

NEUROLOGY | 2003年 / 61卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000086816.30011.75

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease ( SAD) to 40 patients with familial AD ( FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD ( p < 0.001). Genetic factors lead to phenotypic differences in AD.

引用

页码：1138 / 1140

页数：3

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