Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

被引：114
|
作者：
Wu, Peng-fei [1 ]
Zhang, Zui [1 ]
Wang, Fang [1 ,2 ,3 ,4 ,5 ]
Chen, Jian-guo [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharmacol, Wuhan 430030, Peoples R China
[2] Minist Educ China, Key Lab Neurol Dis HUST, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci & Technol, Inst Biomed, Wuhan 430030, Peoples R China
[4] Huazhong Univ Sci & Technol, Inst Drug Discovery, Wuhan 430030, Peoples R China
[5] Hubei Key Lab Nat Drug Chem & Evaluat HUST, Wuhan 430030, Peoples R China
来源：
ACTA PHARMACOLOGICA SINICA | 2010年 / 31卷 / 12期
基金：
中国国家自然科学基金;
关键词：
cerebral ischemia; natural compounds; traditional medicinal herb; ISCHEMIC BRAIN-INJURY; SENSING ION CHANNELS; OXIDATIVE STRESS; IN-VITRO; NITRIC-OXIDE; PC12; CELLS; RAT HEPATOCYTES; FOCAL ISCHEMIA; NEURONAL DEATH; K+-ATPASE;
D O I：
10.1038/aps.2010.186
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.
引用
收藏
页码：1523 / 1531
页数：9
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