Phaeohyphomycosis due to Exophiala spinifera greatly improved by ALA-PDT: A case report

被引：8
|
作者：
Liu, Hongfang [1 ,2 ]
Zhang, Jiao [1 ,2 ]
Chen, Yangxia [1 ,2 ]
Xue, Ruzeng [1 ,2 ]
Zeng, Weiying [1 ,2 ]
Xi, Liyan [1 ,2 ,3 ]
Chen, Yongfeng [1 ,2 ]
机构：
[1] Anhui Med Univ, Guangdong Dermatol Hosp, Guangzhou 510091, Guangdong, Peoples R China
[2] Southern Med Univ, Dermatol Hosp, Guangzhou 510091, Guangdong, Peoples R China
[3] Zhongshan Univ, Sun Yat Sen Mem Hosp, 107 Yanjiang Rd, Guangzhou 510010, Guangdong, Peoples R China
来源：
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2019年 / 28卷
基金：
中国国家自然科学基金;
关键词：
Phaeohyphomycosis; Exophiala spinifera; ITS rDNA; ALA-PDT;
D O I：
10.1016/j.pdpdt.2019.10.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An 80-year-old women complained of painful erythema, papules, nodules on her right wrist for 9 months. Granuloma and inflammatory infiltrates with septate fungal hyphae were observed in pathological sections. Growth of demaciatious fungus on SDA was confirmed to be Exophiala spinifera by microscopic appearance and ITS rDNA sequencing. The diagnosis of phaeohyphomycosis due to E. spinifera was established. The patient had a poor response to oral itraconazole (200 mg/d) combining with terbinafine (250 mg/d) for 6 weeks. Then, following three courses of ALA-PDT, used as adjuvant therapy, skin lesions greatly improved and remained stable after 3 months follow-up. The case suggests that ALA-PDT is an effective adjuvant treatment option for patients with recalcitrant local subcutaneous fungal infection.
引用
收藏
页码：297 / 299
页数：3
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