Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population

被引：42
|
作者：
Vepsalainen, Saila
Parkinson, Michele
Helisalmi, Seppo
Mannermaa, Arto
Soininen, Hilkka
Tanzi, Rudolph E.
Bertram, Lars
Hiltunen, Mikko
机构：
[1] Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
[3] Univ Kuopio, Clin Res Ctr Mediteknia, Brain Res Unit, FIN-70211 Kuopio, Finland
[4] Massachusetts Gen Hosp, Dept Neurol, MassGen Inst Neurodegenerat Dis, Genet & Aging Res Unit, Charlestown, MA USA
[5] Kuopio Univ Hosp, Dept Pathol, SF-70210 Kuopio, Finland
来源：
JOURNAL OF MEDICAL GENETICS | 2007年 / 44卷 / 09期
关键词：
D O I：
10.1136/jmg.2006.048470
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer's disease (AD) based on its ability to degrade amyloid beta-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
引用
收藏
页码：606 / 608
页数：3
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