Topological Characterization of Nucleic Acid G-Quadruplexes by UV Absorption and Circular Dichroism

被引：320
|
作者：
Karsisiotis, Andreas Ioannis [2 ]
Hessari, Nason Ma'ani [2 ]
Novellino, Ettore [4 ]
Spada, Gian Piero [1 ]
Randazzo, Antonio [3 ]
da Silva, Mateus Webba [2 ]
机构：
[1] Alma Mater Studiorum Univ Bologna, Dipartimento Chim Organ A Mangini, I-40126 Bologna, Italy
[2] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland
[3] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[4] Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 45期
基金：
英国生物技术与生命科学研究理事会;
关键词：
circular dichroism; G-quadruplex; nucleic acids; topology; CD SPECTRA;
D O I：
10.1002/anie.201105193
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four-fold: Not just the identification, but also the rapid characterization and classification of nucleic acid G-quadruplexes into topology groups is feasible utilizing UV and circular dichroism (CD) spectroscopy (see picture). It is now possible to utilize inexpensive UV spectroscopy to achieve the same level of characterization previously only possible with CD spectroscopy. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10645 / 10648
页数：4
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