Curcumin-loaded electrospun poly(ε-caprolactone) nanofibrous membrane: An efficient and biocompatible wound-dressing material

被引：4
|
作者：
Bello, Mohammed [1 ]
Abdullah, Faizuan [1 ]
Yusoff, Abdull Rahim Mohd [1 ]
Mahmood, Wan Mohd Asyraf Wan [1 ]
Chee, Tan Yong [1 ]
Malek, Nik Ahmad Nizam Nik [2 ,3 ]
Jemon, Khairunnadwa Binti [2 ,3 ]
Sathishkumar, Palanivel [4 ]
机构：
[1] Univ Teknol Malaysia, Dept Chem, Skudai 81310, Kagawa, Malaysia
[2] Univ Teknol Malaysia, Dept Biosci, Skudai 81310, Kagawa, Malaysia
[3] Univ Teknol Malaysia, Ctr Sustainable Dev, Skudai 813100, Kagawa, Malaysia
[4] SIMATS Saveetha Univ, Saveetha Dent Coll & Hosp, Microbiol & Ecotoxicol Lab, Dept Biomat, Chennai 600077, Tamil Nadu, India
来源：
MATERIALS LETTERS | 2022年 / 315卷
关键词：
Antibacterial activity; Curcumin; Electrospun membrane; Poly(epsilon-caprolactone); Wound-dressing material;
D O I：
10.1016/j.matlet.2022.131910
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The present study aims to produce a natural drug-incorporated nano-based wound-dressing material with high biocompatibility and enhanced antibacterial efficacy for promoting rapid wound healing. Electrospun curcumin-loaded poly(epsilon-caprolactone) (PCL/Cur) membrane is successfully fabricated and characterized using standard techniques. The fabricated PCL/Cur membrane showed a higher antibacterial effect against the bacterial strains, Staphylococcus aureus and Escherichia coli; whereas, a very less cytotoxic effect was observed on the mouse fibroblast (L929) cells. This study concludes that PCL/Cur membrane could be a simple, biocompatible, and efficient material for wound-dressing applications.
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页数：5
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