Either at left or right, both high and low frequency rTMS of dorsolateral prefrontal cortex decreases cue induced craving for methamphetamine

被引:51
|
作者
Liu, Qingming [1 ]
Shen, Ying [2 ]
Cao, Xinyu [3 ]
Li, Yongqiang [2 ]
Chen, Yijiang [4 ]
Yang, Wei [5 ]
Yuan, Ti-Fei [1 ,6 ,7 ,8 ]
机构
[1] Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Rehabil Med Ctr, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
[3] Da Lian Shan Inst Addict Rehabil, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Tech Univ, Mental Hlth Educ Ctr, Nanjing, Jiangsu, Peoples R China
[5] Jilin Univ, Hosp 2, Jilin, Jilin, Peoples R China
[6] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China
[7] Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
[8] Shanghai Jiaotong Univ Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
来源
AMERICAN JOURNAL ON ADDICTIONS | 2017年 / 26卷 / 08期
基金
中国国家自然科学基金;
关键词
TRANSCRANIAL MAGNETIC STIMULATION; TRIAL;
D O I
10.1111/ajad.12638
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background and ObjectivesThe study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues. MethodsThe present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects. ResultsThe results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine. Discussion and ConclusionsIn conclusion, bilateral frontal hemispheres are effective in modulating the cue induced craving to methamphetamine with rTMS. Scientific SignificanceTMS targeting prefrontal cortex is effective for craving modulation; however the mechanism is more than potentiation or depression of single brain region. (Am J Addict 2017;26:776-779)
引用
收藏
页码:776 / 779
页数:4
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