A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome

被引：6
|
作者：
Nakashima, Koki [1 ,2 ]
Fujii, Yuya [1 ]
Sato, Masayuki [1 ,2 ]
Igarashi, Kazunari [1 ]
Kobayashi, Motohiro [3 ]
Ishizuka, Tamotsu [2 ]
机构：
[1] Municipal Tsuruga Hosp, Dept Resp Med, 1-6-60 Mishima Cho, Tsuruga, Fukui 9148502, Japan
[2] Univ Fukui, Fac Med Sci, Dept Internal Med 3, 23-3 Matsuoka Shimoaizuki, Eiheiji, Fukui 9101193, Japan
[3] Univ Fukui, Fac Med Sci, Dept Tumor Pathol, 23-3 Matsuoka Shimoaizuki, Eiheiji, Fukui 9101193, Japan
来源：
RESPIRATORY MEDICINE CASE REPORTS | 2021年 / 34卷
关键词：
Paraneoplastic neurological syndrome (PNS); Amphiphysin (AMPH); Non-small cell lung cancer (NSCLC); Immune checkpoint inhibitor (ICI); Atezolizumab;
D O I：
10.1016/j.rmcr.2021.101525
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor. Blood test results revealed anti-amphiphysin (AMPH) antibody positively, leading to the diagnosis of PNS. The disturbance of consciousness was improved with intravenous administration of steroid and immunoglobulin. To our knowledge, this is the first report of anti-AMPH antibody-positive PNS in a patient with NSCLC.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Anti-SOX1 antibody-positive paraneoplastic neurological syndrome presenting with paraneoplastic encephalomyelitis caused by small-cell lung cancer: A case report
    Iwasa, Kenichi
    Uemasu, Kiyoshi
    Hirayama, Yutaka
    Kitaoka, Aya
    Yasuda, Yuto
    Iwashima, Daisuke
    Tada, Satoru
    Takahashi, Ken-ichi
    CURRENT PROBLEMS IN CANCER: CASE REPORTS, 2021, 4
  • [2] AtezolizumabAnti-amphiphysin antibody-positive paraneoplastic neurological syndrome: case report
    Reactions Weekly, 2022, 1898 (1) : 77 - 77
  • [3] Anti-SOX1 antibody-positive paraneoplastic neurological syndrome presenting with Lambert-Eaton myasthenic syndrome and small cell lung cancer: A case report
    Li, Chunyang
    Wang, Xiaolei
    Sun, Lihua
    Deng, Hui
    Han, Yanqiu
    Zheng, Wenqi
    THORACIC CANCER, 2020, 11 (02) : 465 - 469
  • [4] Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma
    Saiz, A
    Dalmau, J
    Butler, MH
    Chen, Q
    Delattre, JY
    De Camilli, P
    Graus, F
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 66 (02): : 214 - 217
  • [5] Anti-amphiphysin associated limbic encephalitis: a paraneoplastic presentation of small-cell lung carcinoma
    Dorresteijn, LDA
    Kappelle, AC
    Renier, WO
    Gijtenbeek, JMM
    JOURNAL OF NEUROLOGY, 2002, 249 (09) : 1307 - 1308
  • [6] Paraneoplastic syndrome of arthropathies as presenting sign for non-small cell lung cancer
    Lee, Alexander Kyle
    Singh, Gurpreet
    Lewis, Cleveland W.
    CLINICAL CASE REPORTS, 2023, 11 (04):
  • [7] Paraneoplastic Stiff Person Syndrome With Anti-amphiphysin Antibodies Presenting With Pruritus as the Initial Manifestation: An Unusual Case
    Raj, Aiswarya
    Alapatt, Paul
    Johny, Paul
    Ashraf, V. V.
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (02)
  • [8] Anti-amphiphysin associated limbic encephalitis: a paraneoplastic presentation of small-cell lung carcinoma
    Lucille D. A. Dorresteijn
    Arnoud C. Kappelle
    Willy O. Renier
    Johanna M. M. Gijtenbeek
    Journal of Neurology, 2002, 249 : 1307 - 1308
  • [9] Paraneoplastic stiff person syndrome with anti-amphiphysin antibodies presenting with pruritus as the initial manifestation: An unusual case
    Raj, Aiswarya
    Alapatt, Paul
    Johny, Paul
    Ashraf, V. V.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [10] Paraneoplastic Stiff Person Syndrome in Early-Stage Breast Cancer with Positive Anti-Amphiphysin Antibodies
    Vacaras, Vitalie
    Cucu, Enia Eleonora
    Radu, Roxana
    Muresanu, Dafin Fior
    CASE REPORTS IN NEUROLOGY, 2020, 12 (03) : 339 - 347
12345