Synthesis of Novel β-Double-bridged Porphyrin Dimers and Their Photosensitive Activity Investigation

被引：0

作者：

Huang Qi-Mao ^{[1
]}

Li Zhi-Yuan ^{[1
]}

Pan Wei ^{[1
]}

Pan Zhi-Quan ^{[1
]}

Deng Peng-Xing ^{[1
]}

Xiao Xin ^{[1
]}

机构：

[1] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan 430073, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2010年 / 31卷 / 07期

关键词：

Double-bridged porphyrin dimer; DNA; Photosensitive activity; ELECTRON-TRANSFER; DNA;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four novel beta-double-bridged porphyrin dimers were designed and synthesized for the purpose of their photosensitivity and structure-activity relationship study. Their structures were characterized by UV, H-1 NMR, IR, MS and elementary analysis. The ability of singlet oxygen production for the porphyrin dimmers under photo irradiation were determined with DPBF as the quencher. Its photosensitive cleavage ability to pBR322 plasmid DNA has been tested by gel electrophoresis. The interaction of the porphyrin dimer with CT DNA was detected by UV-Vis spectroscopy. The results showed that novel beta-double-bridged porphyrin dimers exhibit obvious photosensitive cleavage activity on DNA, resulting from its well binding effects, which is better than that of beta-single-bridged porphyrin dimer correspondly.

引用

页码：1309 / 1313

页数：5

共 19 条

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