Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis

被引：0
|
作者：
Zhang, XH [1 ]
Sun, GQ [1 ]
Yang, Y [1 ]
Zhang, TH [1 ]
机构：
[1] Gen Hosp Nanjing Command, PLA, Dept Pathol, Nanjing 210002, Peoples R China
来源：
ASIAN JOURNAL OF ANDROLOGY | 2001年 / 3卷 / 01期
关键词：
condylomata acuminata; penile diseases; carcinoma; HPV; protein p53;
D O I：
暂无
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Aim: To determine the immunoreactive pattern of human papillomavirus (HPV) antigen and p53 protein in condylomata acuminatum (CA) and squamous cell carcinoma (SCC) of penis. Methods: Immunohistochemistry for HPV and p53 were performed in 40 specimens of formalin fixed, paraffin embedded tissues using a polyclonal (rabbit) antibody against HPV and a monoclonal (mouse) antibody against human p53 protein. Twenty one cases of CA and nineteen cases of SCC were examined. Results: HPV antigen was detected in all 21 CA and 2 penile SCC. p53 protein overexpression was observed in 12 of 19 (63%) SCC in which G cases were strong positive. Five of 21 CA (24%) showed low-grade p53 protein overexpression. Conclusion: CA is related to HPV infection and some cases show p53 protein low-grade overexpression. In contrast, p53 protein overexpression is common in penile SCC, which is seldom related to HPV infection.
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页码：75 / 77
页数：3
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