Generation of urinary steroid profiles in patients with adrenal incidentaloma using gas chromatography-mass spectrometry

被引：3
|
作者：
Velikanova, L. I. [1 ]
Strel'nikova, E. G. [1 ]
Obedkova, E. V. [1 ]
Krivokhizhina, N. S. [1 ]
Shafigullina, Z. R. [1 ]
Grigoryan, K. [1 ]
Povarov, V. G. [2 ]
Moskvin, A. L. [2 ]
机构：
[1] Northwestern State Med Univ, Ul Kirochnaya 41, St Petersburg 191015, Russia
[2] St Petersburg State Univ, Univ Skii Pr 26, St Petersburg 198504, Russia
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2016年 / 71卷 / 07期
关键词：
gas chromatography-mass spectrometry; urinary steroid profile; incidentaloma; adrenal glands; adrenocortical cancer; DIAGNOSIS; CORTISOL;
D O I：
10.1134/S1061934816070169
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method is developed for the determination of steroid hormones in urine using gas chromatography with mass-spectrometric detection. Sample preparation procedure and the conditions of chromatographic analysis were optimized, and characteristic urinary steroid profiles of patients with adrenocortical cancer were obtained. Criteria for the evaluation of the deficiency of 21-hydroxylase and 11 beta-hydroxylase in patients with adrenal incidentaloma are proposed.
引用
收藏
页码：748 / 754
页数：7
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