Differential Expression and Function of Peroxiredoxin 1 and Peroxiredoxin 6 in Cancerous MCF-7 and Noncancerous MCF-10A Breast Epithelial Cells

被引：21
|
作者：
Goncalves, Kevin [1 ]
Sullivan, Katie [1 ]
Phelan, Shelley [1 ]
机构：
[1] Fairfield Univ, Coll Arts & Sci, Dept Biol, Fairfield, CT 06824 USA
来源：
CANCER INVESTIGATION | 2012年 / 30卷 / 01期
关键词：
Breast cancers; Gene expression; Molecular biology; OXIDATIVE STRESS; 1-CYS PEROXIREDOXIN; ANTIOXIDANT DEFENSE; TUMOR SUPPRESSION; GENE-EXPRESSION; LUNG INJURY; C-MYC; PROTEIN; OVEREXPRESSION; APOPTOSIS;
D O I：
10.3109/07357907.2011.629382
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peroxiredoxins are thiol-specific antioxidant proteins whose expression is elevated in several cancers. We compared the expression and function of Prdx1 and Prdx6 between the MCF-7mammary adenocarcinoma cell line and the noncancerous MCF-10A cell line. We found elevated Prdx1 expression in MCF-7 cells and comparable expression of Prdx6. Suppression of Prdx1 and/or Prdx6 resulted in a modest increase in peroxide-induced cytotoxicity of MCF-7 cells, and a dramatic increase in MCF-10A cytotoxicity with and without hydrogen peroxide treatment. Our data confirm a cytoprotective role for peroxiredoxins and suggest a synergistic role for Prdx1 and Prdx6 in MCF-10A cells.
引用
收藏
页码：38 / 47
页数：10
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