Modulation of GRO-α and TNF-α production by peripheral blood mononuclear cells treated with killed helicobacter pylori

被引：16
|
作者：
Stassi, G. [1 ]
Cascio, A. [2 ]
Iaria, C. [2 ]
Gazzara, D. [1 ]
Costa, G. B. [1 ]
Iannello, D. [1 ]
Arena, A. [1 ]
机构：
[1] Policlin Univ, Dept Surg Sci, Microbiol Unit, Messina, Italy
[2] Policlin Univ, Dept Human Pathol, Infect Dis Sect, Messina, Italy
来源：
EUROPEAN JOURNAL OF INFLAMMATION | 2007年 / 5卷 / 02期
关键词：
GRO-alpha; TNF-alpha; helicobacterpylori; PBMC;
D O I：
10.1177/1721727X0700500204
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
GRO-alpha seems to play an important role in recruiting and activating neutrophils during Helicobacter pylori infection. In the present study, we examined how treatment with killed H. pylori or/and live H. pylori may differentially influence the in vitro GRO-alpha and TNF-alpha release by peripheral blood mononuclear cells (PBMC). The amounts of TNF-alpha and GRO-alpha produced by PBMC after stimulation with live H. pylori were higher than those produced after stimulation with a combination of killed and live H. pylori and the latter were higher than those produced after stimulation with killed H. pylori. In conclusion, the treatment of peripheral blood mononuclear cells with killed H. pylori down-regulates the production of GRO-alpha. Taken together, our data demonstrate that treatment with killed H. pylori could represent an innovative approach during gastric infection supported by H. pylori.
引用
收藏
页码：83 / 88
页数：6
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