Liver Regeneration after Liver Transplantation

被引：43
|
作者：
Taki-Eldin, A. [1 ]
Zhou, L. [1 ]
Xie, H. -Y. [1 ]
Zheng, S. -S. [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Key Lab Combined Multiorgan Transplantat, Minist Publ Hlth,Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
来源：
EUROPEAN SURGICAL RESEARCH | 2012年 / 48卷 / 03期
关键词：
Liver regeneration; Transplantation; Cytokines; Growth factors; Graft size; HEPATOCYTE GROWTH-FACTOR; TUMOR-NECROSIS-FACTOR; ADULT LIVING DONOR; HEPATITIS-C VIRUS; INTEGRIN-LINKED KINASE; RAT-LIVER; PARTIAL-HEPATECTOMY; FACTOR-ALPHA; CELL-PROLIFERATION; TGF-BETA;
D O I：
10.1159/000337865
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background/Purpose: The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation. Methods: Relevant studies were reviewed using Medline, PubMed and Springer databases. Results: A variety of cytokines (such as interleukin-6 and tumor necrosis factor-alpha), growth factors (like hepatocyte growth factor and transforming growth factor-alpha) and cells are involved in liver regeneration. Several factors affect liver regeneration after transplantation such as ischemic injury, graft size, immunosuppression, steatosis, donor age and viral hepatitis. Conclusion: Liver regeneration has been studied for many years. However, further research is essential to reveal the complex processes affecting liver regeneration, which may provide novel strategies in the management of liver transplantation recipients and donors. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：139 / 153
页数：15
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