Ent-kaurene diterpenoids and lignan from Leontopodium leontopodioides and their inhibitory activities against cyclooxygenases-1 and 2

被引：10
|
作者：
Qi, Chu-Lu [1 ]
Wang, En [1 ]
Jin, Li-Qin [1 ]
Yan, Ming [2 ]
Zhang, Xiao-Qi [3 ]
Wang, Hao [1 ]
Ye, Wen-Cai [3 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China
[3] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2017年 / 21卷
基金：
中国国家自然科学基金;
关键词：
Leontopodium leontopodioides; Asteraceae; Ent-kaurene diterpenoid; Lignan; Phenolic acid; Cyclooxygenases; DERIVATIVES;
D O I：
10.1016/j.phytol.2017.06.019
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new ent-kaurene diterpenoids, 13a, 15a-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2 beta-O-(2'-angelate)beta- D-glucopyranoside (leontocin A, 1), 13a, 15a-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2 beta-O-(2'-angelate6'- acetyl)-beta-D-glucopyranoside (leontocin B, 2), and one new lignan, 2,3-bis[(3,4-di-hydroxyphenyl) methylene]monoethyl ester-butanedioic acid (leontolignan A, 3), together with three known phenolic acids (4-6) were isolated from the aerial parts of Leontopodium leontopodioides (Asteraceae). Their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for their anti-inflammatory activities by measuring their inhibitory effects against cyclooxygenase-1 and 2 in vitro.
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收藏
页码：94 / 97
页数：4
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